activation loop in a sentence

1) Full activity is only achieved once these dimers transphosphorylate each other on their activation loops .

2) The structure of Bcr-Abl contains two flexible loops, the ATP-binding P-loop and the activation loop .

3) KSRs cannot undergo this last step as they miss any phosphorylatable residues in their activation loops .

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activation loop example sentences

4) In order to become active, they require (potentially multiple) phosphorylation events in their activation loops .

5) To achieve full activity and stabilize the active state, the activation loop of c-Raf needs to be phosphorylated.

6) Meanwhile, the phosphorylated residue approaches K507, forming a stabilizing salt bridge to lock the activation loop into place.

7) When the activation loop is phosphorylated, the negative charge of the phosphate is unstable in the hydrophobic environment of the P-loop.

8) Class I inhibitors have many different structures, are relatively selective and have a U-shaped conformation and binds to the activation loop of c-Met.

9) Mutations on other sites of the kinase have also been reported, for example on the C-helix, SH2 domain, substrate binding site, activation loop and C-terminal lobe.

10) It then binds key activation loop and DFG motif residues to stop the movement of the activation loop and DFG motif to the active conformation.

11) It then binds key activation loop and DFG motif residues to stop the movement of the activation loop and DFG motif to the active conformation.

12) These MKKs become phosphorylated at at least two sites on their activation loops upon binding to Raf: this will activate them too.

13) One such site (the DEF site) is formed by the activation loop (when in the active conformation) and the MAP kinase-specific insert below it.