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While this assumption may be a reasonable first approximation, it does not allow for the possibility of a cross-product relationship in which a group-specific variable (for example, toxic exposure) might lead to informative sub-states that exhibit separate groups of coordinately regulated responsive genes as a function of the extent to which the individual responds.

In fibroblast models, these GTPases have been proposed to act in a concerted hierarchy to coordinately regulate distinct morphological features.

In order to fully understand IL-8's role in these events, it is important to investigate these coordinately expressed genes.

In keeping with these findings, ex vivo experiments with human thymocytes previously reported by our group, revealed that while phorbol esters can coordinately regulate the transcription of ?

and ß TCR during intrathymic T cell differentiation [ 14 ] , cAMP selectively affected the transcription of the ?

and ?

-TCR [ 15 16 ] .

Since (a) it is generally accepted that CD4 or CD8 are physically associated to the TCR in the course of T cell activation [ 17 18 ] and (b) it is well known that mitogen activated protein (MAP) kinase signaling is involved in the selection of the T cell repertoire [ 19 20 ] , the present study further proposes that the PKC and PKA-mediated signaling, which regulates TCR expression, can coordinately modulate the selection of CD4 +CD8 -and CD4 -CD8 +T cells during human intrathymic differentiation.

As it can also be observed, cAMP coordinately regulated the expression of both the ?

and ß chains of the CD8 molecule.

These conditions were chosen because the RNAseH and polymerase activities function coordinately during reverse transcription, and hence it is reasonable to assume they operate under similar conditions.

This result suggests that the two sectors of the complex are not necessarily coordinately expressed.

It is also not yet known whether the Cpn 1054 gene family is expressed individually or coordinately, or to what extent each gene is expressed during the course of an infection.

We considered an extreme model to account for our observations - that evolutionary selection has organized gene groups according to the biological processes the genes are involved in, so that their expression can be coordinately regulated.

IL-1ß coordinately reduced expression of integrin a1, a cell-adhesion molecule that chondrocytes use to bind to type II collagen [ 48].

To simplify this task, genes whose products function together are often under common regulatory control such that they are coordinately expressed under the appropriate conditions.

For example, the known targets of the oxidative stress-responsive transcription factor Yap1p are coordinately induced in response to conditions that inflict oxidative damage, but these genes are divergently expressed in response to other environmental changes (Figure 1c) [ 2].

However, this set of genes was not coordinately expressed during cell-cycle progression [ 54, 55], suggesting that these cell-wall genes may be regulated by a distinct mechanism in response to environmental conditions.

The transcript encoding ornithine decar-boxylase (ODC), a known androgen target that catalyzes the rate-limiting step in polyamine biosynthesis [ 26], was induced coordinately with enzymes that catalyze downstream steps in polyamine synthetic pathway (spermine synthase, spermidine/spermine N 1-acetyltransferase, and S-adenosylmethionine decarboxylase) (Figure 5c).

Of these genes, all but 6 were included among the 93 genes coordinately expressed in the in vitro and in vivo time courses (Figure 3).

A second node included 28 genes consistently downregulated, most of them represented among those coordinately downregulated in the time-course studies.

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The word coordinately